AUL - Revision history

John at 09:27, 22 December 2023

2023-12-22T09:27:23Z

John at 20:50, 21 December 2023

2023-12-21T20:50:43Z

← Older revision		Revision as of 22:50, 21 December 2023
Line 7:		Line 7:

	----		----

	<span id="anchor_0">‎</span>.		<span id="anchor_0">‎</span>.
	<div style="width: 100%; border: 1px solid black; font-size:100%">		<div style="width: 100%; border: 1px solid black; font-size:100%">

John at 20:49, 21 December 2023

2023-12-21T20:49:31Z

← Older revision		Revision as of 22:49, 21 December 2023
Line 27:		Line 27:
	\|}		\|}
	</div>		</div>

			----

John at 20:49, 21 December 2023

2023-12-21T20:49:14Z

← Older revision		Revision as of 22:49, 21 December 2023
Line 7:		Line 7:

	----		----


	<span id="anchor_0">‎</span>.		<span id="anchor_0">‎</span>.

John at 20:48, 21 December 2023

2023-12-21T20:48:57Z

← Older revision		Revision as of 22:48, 21 December 2023
Line 13:		Line 13:
	{\| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0"		{\| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0"
	!colspan="2" <span style="font-size:90%; font-color:navy; style="text-align: left; border: 1px solid black; background:pale gray">\|'''What features must be met to diagnose acute undifferentiated leukaemia'''</br></span>		!colspan="2" <span style="font-size:90%; font-color:navy; style="text-align: left; border: 1px solid black; background:pale gray">\|'''What features must be met to diagnose acute undifferentiated leukaemia'''</br></span>
	~~<div class="mw-collapsible mw-collapsed" data-expandtext="Click for explanation" data-collapsetext="Hide explanation">~~
	~~<div class="mw-collapsible-content">~~
	<span style="font-size:80%; text-align:left;"></br>This is a difficult area where the diagnosis of acute leukaemia is suspected but no criteria for lineage assignment can be made i.e. the cases do not meet any of the criteria for myeloid, B-lymphoid, or T-lymphoid lineage given above. An important aspect of this group is to exclude the possibility of rare entities that can mimic AML: these include non-haemaotopoietic neoplasm and blastic plasma cell dendritic neoplasm.</br>
	~~</span>~~
	~~</div></div></div>~~
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 1'''		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 1'''

John at 12:56, 21 December 2023

2023-12-21T12:56:02Z

← Older revision		Revision as of 14:56, 21 December 2023
Line 1:		Line 1:
			----
			<div style="width: 200px">
			{\| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy"
			\| colspan="1"''\|[[The flow cytometric diagnosis of AML\|Return to previous page]]''
			\|}
			</div>

			----


	<span id="anchor_0">‎</span>.		<span id="anchor_0">‎</span>.
	<div style="width: 100%; border: 1px solid black; font-size:100%">		<div style="width: 100%; border: 1px solid black; font-size:100%">

John at 16:20, 24 November 2023

2023-11-24T16:20:20Z

← Older revision		Revision as of 18:20, 24 November 2023
Line 11:		Line 11:
	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 1'''		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 1'''
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black;"\|~~'''Required'''~~ No lineage can be assigned by lineage-defining markers of myeloid, B-lymphoid or T-lymphoid lineage		\|colspan="2" style = "font-size:90%; color:black;"\|No lineage can be assigned by lineage-defining markers of myeloid, B-lymphoid or T-lymphoid lineage
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 2'''		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 2'''

John at 16:19, 24 November 2023

2023-11-24T16:19:30Z

← Older revision		Revision as of 18:19, 24 November 2023
Line 11:		Line 11:
	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 1'''		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 1'''
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black;"\|'''Required''' No lineage ~~assignment~~ can be ~~made based on single~~ lineage-defining myeloid, B-lymphoid or T-lymphoid ~~msrkers i.e. do not express MPO, CD3, strong CD19, cyCD22 or cyCD79a~~		\|colspan="2" style = "font-size:90%; color:black;"\|'''Required''' No lineage can be assigned by lineage-defining markers of myeloid, B-lymphoid or T-lymphoid lineage
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 2'''		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 2'''
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black;"\|No more than one lineage-associated ~~(but not lineage-defining~~ marker) for any lineage ~~should be~~ expressed		\|colspan="2" style = "font-size:90%; color:black;"\|No more than one lineage-associated marker for any single lineage is expressed
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 3'''		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 3'''
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black;"\|~~Markers mainly associated with the primitive nature of leukaemic cells do not allow lineage assignment (e.g. CD34, HLA-DR, TdT, CD7, CD38) and are frequently seen in undifferentiated acute leukaemia~~		\|colspan="2" style = "font-size:90%; color:black;"\|Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider: acute megakaryocytic leukaemia, non haematopoietic tumours, blastic plasma dendritic cell neoplasm, and rarely plasma cell leukaemias.
	\|-
	~~\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" \|'''Requirement 4'''~~
	\|-
	~~\|colspan="2" style = "font-size:90%; color:black;"\|It is essential~~ that other conditions that may resemble undifferentiated acute leukaemia are excluded: ~~these may particu;arly include~~: acute megakaryocytic leukaemia, non haematopoietic tumours, blastic plasma cell ~~dendritic~~ neoplasm, and rarely plasma cell leukaemias~~. In each case this may require consideration of the wider context of the clinical history and marker pattern~~.
	\|-		\|-
	\|}		\|}
	</div>		</div>

John: Created page with "‎.
{| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" |'''What features must be met to diagnose acute undifferentiated leukaemia'''

2023-10-30T14:54:15Z

Created page with "<span id="anchor_0">‎</span>. <div style="width: 100%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90%; font-color:navy; style="text-align: left; border: 1px solid black; background:pale gray">|'''What features must be met to diagnose acute undifferentiated leukaemia'''</br></span> <div class="mw-collapsible mw-collapsed" data-expandtext="Click for expl..."

New page
<span id="anchor_0">‎</span>.
<div style="width: 100%; border: 1px solid black; font-size:100%">
{| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0"
!colspan="2" <span style="font-size:90%; font-color:navy; style="text-align: left; border: 1px solid black; background:pale gray">|'''What features must be met to diagnose acute undifferentiated leukaemia'''</br></span>
<div class="mw-collapsible mw-collapsed" data-expandtext="Click for explanation" data-collapsetext="Hide explanation">
<div class="mw-collapsible-content">
<span style="font-size:80%; text-align:left;"></br>This is a difficult area where the diagnosis of acute leukaemia is suspected but no criteria for lineage assignment can be made i.e. the cases do not meet any of the criteria for myeloid, B-lymphoid, or T-lymphoid lineage given above. An important aspect of this group is to exclude the possibility of rare entities that can mimic AML: these include non-haemaotopoietic neoplasm and blastic plasma cell dendritic neoplasm.</br>
</span>
</div></div></div>
|-
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''Requirement 1'''
|-
|colspan="2" style = "font-size:90%; color:black;"|'''Required''' No lineage assignment can be made based on single lineage-defining myeloid, B-lymphoid or T-lymphoid msrkers i.e. do not express MPO, CD3, strong CD19, cyCD22 or cyCD79a
|-
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''Requirement 2'''
|-
|colspan="2" style = "font-size:90%; color:black;"|No more than one lineage-associated (but not lineage-defining marker) for any lineage should be expressed
|-
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''Requirement 3'''
|-
|colspan="2" style = "font-size:90%; color:black;"|Markers mainly associated with the primitive nature of leukaemic cells do not allow lineage assignment (e.g. CD34, HLA-DR, TdT, CD7, CD38) and are frequently seen in undifferentiated acute leukaemia
|-
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''Requirement 4'''
|-
|colspan="2" style = "font-size:90%; color:black;"|It is essential that other conditions that may resemble undifferentiated acute leukaemia are excluded: these may particu;arly include: acute megakaryocytic leukaemia, non haematopoietic tumours, blastic plasma cell dendritic neoplasm, and rarely plasma cell leukaemias. In each case this may require consideration of the wider context of the clinical history and marker pattern.
|-
|}
</div>