John at 19:42, 4 July 2023

2023-07-04T19:42:04Z

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	!colspan="8"\|'''Expression in mature B cell neoplasms'''		!colspan="8"\|'''Expression in mature B cell neoplasms'''
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	! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL \|\| LPL !! PCL		! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL \|\| LPL !! PCL
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	\|style="width: 12.5%; background: #00b8e6; color:black"\|20-40%		\|style="width: 12.5%; background: #00b8e6; color:black"\|20-40%
	\|style="width: 12.5%; background: #00b8e6; color:black"\|20-40%*		\|style="width: 12.5%; background: #00b8e6; color:black"\|20-40%*

John at 11:08, 3 July 2023

2023-07-03T11:08:22Z

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	!colspan="8"\|~~<span style="font-size:100%">~~'''Expression in primitive cell types'''</font>		!colspan="8"\|'''Expression in primitive cell types'''</font>
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	! AML !! CMML !! B ALL !! ~~Burkitt~~ \|\| T ALL !! ETP ALL ~~<'''[[ETP ALL\|I]]'''>~~ !! ~~MPAL <'''[[~~MPAL~~\|I]]'''>~~ \|\| ~~Hgns~~ <~~'''[[Hgns\|I]]'''~~>		!AML!!CMML !!B ALL !!BL \|\|T ALL !!ETP ALL !!MPAL \|\|Hgn</span>
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John: Created page with "
:'''Summary''' :Principally a marker of cell activation that is expressed by a range of haematopoietic lineages, The expression of CD25 has value in the diagnosis of several disorders although in each case expression is not fully specific and the level of expression may be key to diagnosis :*High levels of CD25 are typical in hairy cell le..."

2023-05-15T12:34:22Z

Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :'''Summary''' :Principally a marker of cell activation that is expressed by a range of haematopoietic lineages, The expression of CD25 has value in the diagnosis of several disorders although in each case expression is not fully specific and the level of expression may be key to diagnosis :*High levels of CD25 are typical in hairy cell le..."

New page

<div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;">

:'''Summary'''

:Principally a marker of cell activation that is expressed by a range of haematopoietic lineages, The expression of CD25 has value in the diagnosis of several disorders although in each case expression is not fully specific and the level of expression may be key to diagnosis
:*High levels of CD25 are typical in hairy cell leukaemia
:*CD25 is expressed by many malignant mast cells
:*CD25 expression is useful in the identification of Adult T Cell Leukaemia Lymphoma (ATLL)

</div>

'''Normal expression and function'''

CD25 is one subunit (alpha subunit) of the interleukin 2 receptor (IL2), CD25 has broad expression in the immune system but is most frequently a features of cell activation. CD25 associates with a beta subunit on memory T cells and NK cells or with beta and gamma subunits on activated or regulatory T cells to increase its affinity for IL-2 and allowing the activation of intracellular signals that cause cell activation.

'''Diagnostic role'''

CD25 may be expressed by a range of malignant cells; for example many cases of CLL, but detection has value in specific circumstances
* CD25 is expressed by most cases of hairy cell leukemia (HCL) with less expression by related disorders such as splenic marginal zone lymphoma
* The malignant mast cells of systemic mastocytosis express CD25, while normal mast cells generally do not
* CD25 is strongly expressed by the neoplastic T cells in adult T cell leukaemia lymphoma (ATLL) although it is expressed also in other T cell disorders notably T-PLL and Sézary syndrome
* CD25 should may also be expressed in AML (around 10%) and in ALL (around 30% and particularly in cases expressing BCR::ABL1)

'''Other relevant information:'''

In a histlogical context CD25 has a wider diagnostic use staining anaplastic large cell lymphoma, and high frequency and in Hodgkin disease.

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'''''SUMMARY TABLES'''''

'''Note''' The colour and % refer to the proportion of cases expressing the marker. Additional comments on strength, or site of expression (if relevant) are given below the table. For full details of key click [[Key to marker expression table|here]]. For further information about a particular disease state click <'''I'''> adjacent to the condition name

{| class=wikitable style="text-align: center; font-size:80%; width: 100%; height 20px;"
|-
!colspan="8"|'''Expression in primitive cell types'''
|-
! AML !! CMML !! B ALL !! Burkitt || T ALL !! ETP ALL <'''[[ETP ALL|I]]'''> !! MPAL <'''[[MPAL|I]]'''> || Hgns <'''[[Hgns|I]]'''>
|-
|style="width: 12.5%; background: #66e0ff; color:black"|5-20%
|style="width: 12.5%; background: #E6FAFF; color:black"|<5%
|style="width: 12.5%; background: #66e0ff; color:black"|5-20%
|style="width: 12.5%; background: #E6FAFF; color:black"|<5%
|style="width: 12.5%; background: #E6FAFF; color:black"|<5%
|style="width: 12.5%; background: #E6FAFF; color:black"|<5%
|style="width: 12.5%; background: #E6FAFF; color:black"|<5%
|style="width: 12.5%; background: #E6FAFF; color:black"|<5%
|-
|}

'''Notes:''' Expression in B-ALL may be associated with ''BCR::ABL1'' expression 

{| class=wikitable style="text-align: center; font-size:80%; width: 100%; height 20px;"
|-
!colspan="8"|'''Expression in mature B cell neoplasms'''
|-
! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL || LPL !! PCL
|-
|style="width: 12.5%; background: #00b8e6; color:black"|20-40%
|style="width: 12.5%; background: #00b8e6; color:black"|20-40%*
|style="width: 12.5%; background: #66e0ff; color:black"|5-20%
|style="width: 12.5%; background: #00b8e6; color:black"|20-40%
|style="width: 12.5%; background: #004466; color:white"|80-100%**
|style="width: 12.5%; background: #66e0ff; color:black"|5-20%
|style="width: 12.5%; background: #006699; color:white"|40-80%
|style="width: 12.5%; background: #E6FAFF; color:black"|<5%
|-
|}

'''Notes:''' *Expression is not always seen in MCL but may have high intensity **Strong expression intensity is expected in HCL

{| class=wikitable style="text-align: center; font-size:80%; width: 62.4%; height 40px;"
|-
!colspan="7"|'''Expression in mature T cell neoplasms*'''
|-
! ATLL !! CTCL/Sezary !! T-PLL !! T-LGL !! NK-LGL
|-
|style="width: 14.25%; background: #004466; color:white"|80-100%*
|style="width: 14.25%; background: #006699; color:white"|40-80%
|style="width: 14.25%; background: #66e0ff; color:black"|5-20%
|style="width: 14.25%; background: #E6FAFF; color:wblack"|<5%
|style="width: 14.25%; background: #E6FAFF; color:wblack"|<5%
|-
|}

'''Notes:''' CD25 has characteristically strong expression on ATLL, but other T-LPD also express the marker less strongly 

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CD25 - Revision history

John at 19:42, 4 July 2023

John at 11:08, 3 July 2023