CD34 - Revision history

John at 19:43, 4 July 2023

2023-07-04T19:43:24Z

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	!colspan="8"\|'''Expression in mature B cell neoplasms'''		!colspan="8"\|'''Expression in mature B cell neoplasms'''
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	! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL \|\| LPL !! PCL		! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL \|\| LPL !! PCL
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John at 11:10, 3 July 2023

2023-07-03T11:10:11Z

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	!colspan="8"\|~~<span style="font-size:100%">~~'''Expression in primitive cell types'''</font>		!colspan="8"\|'''Expression in primitive cell types'''</font>
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	! AML !! CMML !! B ALL !! ~~Burkitt~~ \|\| T ALL !! ETP ALL ~~<'''[[ETP ALL\|I]]'''>~~ !! ~~MPAL <'''[[~~MPAL~~\|I]]'''>~~ \|\| ~~Hgns~~ <~~'''[[Hgns\|I]]'''~~>		!AML!!CMML !!B ALL !!BL \|\|T ALL !!ETP ALL !!MPAL \|\|Hgn</span>
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	\|style="width: 12.5%; background: #006699; color:white"\|40-80%*		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
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John at 11:03, 17 May 2023

2023-05-17T11:03:29Z

← Older revision		Revision as of 13:03, 17 May 2023
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	:<span style="color:navy">'''Summary'''</span>		:<span style="color:navy">'''Summary'''</span>

	:Often regarded as a marker of primitive phenotype, CD34 is expressed by many cases of ALL (around 50%) and slightly fewer cases of AML around (40%). CD34 is also expressed by regenerating cells in marrow. It is particularly expressed by regenerating B lymphocytes (haematogones), but is generally absent from mature haematopoietic cells.		:Often regarded as a marker of primitive phenotype, CD34 is expressed by many cases of ALL (around 50%) and slightly fewer cases of AML around (40%). CD34 is also expressed by regenerating cells in marrow. It is particularly expressed by regenerating B lymphocytes (haematogones), but is generally absent from mature haematopoietic cells, lower expression in AML may be seen in APL, and in ALL may suggest Burkitt lymphome.


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	*CD34 is commonly used to identify the primitive nature of early lymphoid or myeloid cells i.e. blast cells of ALL and AML		*CD34 is commonly used to identify the primitive nature of early lymphoid or myeloid cells i.e. blast cells of ALL and AML
	*Rare very primitive cases of acute leukaemia may be identified solely through their expression of CD34 and CD45		*Rare very primitive cases of acute leukaemia may be identified solely through their expression of CD34 and CD45
	*~~CD45~~ is also expressed by regenerating cells in marrow and also by regenerating haematogones so caution is necessary in interpretation in regenerating marrows		*CD34 is also expressed by regenerating cells in marrow and also by regenerating haematogones so caution is necessary in interpretation in regenerating marrows


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	<span style="font-size:90%">'''Notes:''' ~~xxxxx~~ </span>		<span style="font-size:90%">'''Notes:''' '''' In acute leukaemias expression is frequent but not absolute and tends to be expressed on less more mature forms '''' expression on CMMl is infrequent and may be abberant, but may also indicate transformation to an acute leukaemia, ''**'' Haematones typically express CD34, but it is lost on more mature haematogones </span>

John at 10:58, 17 May 2023

2023-05-17T10:58:07Z

← Older revision		Revision as of 12:58, 17 May 2023
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	~~<span style="font-size:90%">'''Notes:''' xxxxx </span>~~


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	! ATLL !! CTCL/Sezary !! T-PLL !! T-LGL !! NK-LGL		! ATLL !! CTCL/Sezary !! T-PLL !! T-LGL !! NK-LGL
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	\|style="width: 14.25%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|? <5~~% 5-20% 20-40% 40-80% 80-100~~%		\|style="width: 14.25%; background: #E6FAFF; color:black"\|<5%
	\|style="width: 14.25%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|? <5~~% 5-20% 20-40% 40-80% 80-100~~%		\|style="width: 14.25%; background: #E6FAFF; color:black"\|<5%
	\|style="width: 14.25%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|? <5~~% 5-20% 20-40% 40-80% 80-100~~%		\|style="width: 14.25%; background: #E6FAFF; color:black"\|<5%
	\|style="width: 14.25%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|? <5~~% 5-20% 20-40% 40-80% 80-100~~%		\|style="width: 14.25%; background: #E6FAFF; color:black"\|<5%
	\|style="width: 14.25%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|? <5~~% 5-20% 20-40% 40-80% 80-100~~%		\|style="width: 14.25%; background: #E6FAFF; color:black"\|<5%
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	\|}		\|}

	~~<span style="font-size:90%">'''Notes:''' xxxxx </span>~~

	----		----

John at 10:56, 17 May 2023

2023-05-17T10:56:39Z

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John at 10:55, 17 May 2023

2023-05-17T10:55:03Z

← Older revision		Revision as of 12:55, 17 May 2023
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	! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL \|\| LPL !! PCL		! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL \|\| LPL !! PCL
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	\|style="width: 12.5%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|? <5~~% 5-20% 20-40% 40-80% 80-100~~%		\|style="width: 12.5%; background: #E6FAFF; color:black"\|<5%
	\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%		\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%
	\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%		\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%

John at 10:53, 17 May 2023

2023-05-17T10:53:50Z

← Older revision		Revision as of 12:53, 17 May 2023
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	! AML !! CMML !! B ALL !! Burkitt \|\| T ALL !! ETP ALL <'''[[ETP ALL\|I]]'''> !! MPAL <'''[[MPAL\|I]]'''> \|\| Hgns <'''[[Hgns\|I]]'''>		! AML !! CMML !! B ALL !! Burkitt \|\| T ALL !! ETP ALL <'''[[ETP ALL\|I]]'''> !! MPAL <'''[[MPAL\|I]]'''> \|\| Hgns <'''[[Hgns\|I]]'''>
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	\|style="width: 12.5%; background: #006699; color:white"\|40-80%		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|~~? <5%~~ 5-20% ~~20-40% 40-80% 80-100%~~		\|style="width: 12.5%; background: #E6FAFF; color:black"\|5-20%**
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20~~#66e0ff ~~40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|~~? <5%~~ 5-20~~% 20-40% 40-80% 80-100~~%		\|style="width: 12.5%; background: #66e0ff; color:black"\|5-20%
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%***

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John at 10:47, 17 May 2023

2023-05-17T10:47:15Z

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	! AML !! CMML !! B ALL !! Burkitt \|\| T ALL !! ETP ALL <'''[[ETP ALL\|I]]'''> !! MPAL <'''[[MPAL\|I]]'''> \|\| Hgns <'''[[Hgns\|I]]'''>		! AML !! CMML !! B ALL !! Burkitt \|\| T ALL !! ETP ALL <'''[[ETP ALL\|I]]'''> !! MPAL <'''[[MPAL\|I]]'''> \|\| Hgns <'''[[Hgns\|I]]'''>
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	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80~~% 80-100~~%		\|style="width: 12.5%; background: #006699; color:white"\|40-80%
	\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%		\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%
	\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%		\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%

John at 10:46, 17 May 2023

2023-05-17T10:46:01Z

← Older revision		Revision as of 12:46, 17 May 2023
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	<span style="color:navy">'''Other relevant information:'''</span>		<span style="color:navy">'''Other relevant information:'''</span>

	~~xxxxx~~		Histopathologists often use CD34 to demonstrate the number of primitive cells in bone marrow trephine biopsies e.g. in the assessment of primitive cell number in myelodysplaia. However, a range of other cell types in bone marrow also express CD34 in marrow, and these include vascular endothelial cells and mast cells.

John at 10:44, 17 May 2023

2023-05-17T10:44:48Z

← Older revision		Revision as of 12:44, 17 May 2023
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	<span style="color:navy">'''Diagnostic role'''</span>		<span style="color:navy">'''Diagnostic role'''</span>

	*~~xxxxx~~		*CD34 is commonly used to identify the primitive nature of early lymphoid or myeloid cells i.e. blast cells of ALL and AML
			*Rare very primitive cases of acute leukaemia may be identified solely through their expression of CD34 and CD45
			*CD45 is also expressed by regenerating cells in marrow and also by regenerating haematogones so caution is necessary in interpretation in regenerating marrows

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	! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL \|\| LPL !! PCL		! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL \|\| LPL !! PCL
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	\|style="width: 12.5%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|? <5~~% 5-20% 20-40% 40-80% 80-100~~%		\|style="width: 12.5%; background: #E6FAFF; color:black"\|<5%
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	\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%		\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%

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	! AML !! CMML !! B ALL !! Burkitt \|\| T ALL !! ETP ALL <'''[[ETP ALL\|I]]'''> !! MPAL <'''[[MPAL\|I]]'''> \|\| Hgns <'''[[Hgns\|I]]'''>		! AML !! CMML !! B ALL !! Burkitt \|\| T ALL !! ETP ALL <'''[[ETP ALL\|I]]'''> !! MPAL <'''[[MPAL\|I]]'''> \|\| Hgns <'''[[Hgns\|I]]'''>
	\|-		\|-
	\|style="width: 12.5%; background: #006699; color:white"\|40-80%		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5~~#E6FAFF ~~20#66e0ff 40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|~~? <5%~~ 5-20% ~~20-40% 40-80% 80-100%~~		\|style="width: 12.5%; background: #E6FAFF; color:black"\|5-20%**
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20~~#66e0ff ~~40#00b8e6 80#006699;100#004466~~; color:~~white~~ black"\|~~? <5%~~ 5-20~~% 20-40% 40-80% 80-100~~%		\|style="width: 12.5%; background: #66e0ff; color:black"\|5-20%
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%*
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80% ~~80-100%~~		\|style="width: 12.5%; background: #006699; color:white"\|40-80%***

	\|-		\|-
	\|}		\|}

← Older revision		Revision as of 12:47, 17 May 2023
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	! AML !! CMML !! B ALL !! Burkitt \|\| T ALL !! ETP ALL <'''[[ETP ALL\|I]]'''> !! MPAL <'''[[MPAL\|I]]'''> \|\| Hgns <'''[[Hgns\|I]]'''>		! AML !! CMML !! B ALL !! Burkitt \|\| T ALL !! ETP ALL <'''[[ETP ALL\|I]]'''> !! MPAL <'''[[MPAL\|I]]'''> \|\| Hgns <'''[[Hgns\|I]]'''>
	\|-		\|-
	\|style="width: 12.5%; background: ~~?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80~~#006699~~;100#004466~~; color:white ~~black~~"\|~~? <5% 5-20% 20-40%~~ 40-80~~% 80-100~~%		\|style="width: 12.5%; background: #006699; color:white"\|40-80%
	\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%		\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%
	\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%		\|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"\|? <5% 5-20% 20-40% 40-80% 80-100%