Hemighost cells - Revision history

John at 13:44, 27 March 2023

2023-03-27T13:44:36Z

← Older revision		Revision as of 15:44, 27 March 2023
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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''Images''' ''The typical appearance of a hemighost, the haemoglobin is dense and is contracted to one pole of the cell to leave an area where membrane surrounds an “empty” area – the blister.''		'''Images''' ''The typical appearance of a hemighost or blister cell, the haemoglobin is dense and is contracted to one pole of the cell to leave an area where membrane surrounds an “empty” area – the blister. This cell is a form of irregularly contracted cell which often accompany them''
	</span>		</span>

John at 13:43, 27 March 2023

2023-03-27T13:43:28Z

← Older revision		Revision as of 15:43, 27 March 2023
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	<gallery mode="nolines" widths="240px" heights="240px" border="1px" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	File:~~HG1~~.png\|link={{filepath:HG1.png}}		File:HG1A.png\|link={{filepath:HG1.png}}
	File:HG2.jpg\|link={{filepath:HG2.jpg}}		File:HG2.jpg\|link={{filepath:HG2.jpg}}
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John at 09:52, 9 March 2023

2023-03-09T09:52:52Z

← Older revision		Revision as of 11:52, 9 March 2023
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	<gallery mode="nolines" widths="240px" heights="240px" border="1px" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	~~File:~~File:HG1.png\|link={{filepath~~:File~~:HG1.png}}		File:HG1.png\|link={{filepath:HG1.png}}
	File:HG2.jpg\|link={{filepath:HG2.jpg}}		File:HG2.jpg\|link={{filepath:HG2.jpg}}
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John at 09:39, 9 March 2023

2023-03-09T09:39:32Z

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 Hemighost cells arise when haemoglobin is damaged (similar to irregularly contracted cells with which they frequently co-exist). The hemighost appearance occurs particularly where there is oxidative damage and often indicates a deficiency of the protective enzyme glucose 6 phosphate dehydrogenase (which generates reducing power). The disorder particularly affects at-risk populations from Africa or Mediterranean origin). Hemighost formation therefore can be an acute event associated with progressive anaemia that requires immediate intervention. The presence of hemighost cells as a dominant feature should therefore be taken very seriously and reported urgently to clinical staff caring for the patient.
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 <span style="font-style:italic; font-size:90%;'' >
 '''''Clinical Image 3: '''This is s severe oxidative haemolysis in which hemighost cells can be easily seen, but note also an additional abnormal cell type is a red cells that contain no haemoglobin “ghost cells” reflecting the severity of the oxidative process. Clinical condition: severe oxidative haemolysis

John at 09:38, 9 March 2023

2023-03-09T09:38:32Z

← Older revision		Revision as of 11:38, 9 March 2023
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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:~~aaa~~.jpg\|link={{filepath:~~aaa~~.jpg}}		File:HG3.jpg\|link={{filepath:HG3.jpg}}
	</gallery>		</gallery>


	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''''Clinical Image 1: '''~~aaa~~''		'''''Clinical Image 1: '''The typical appearance of a hemighost (“blister cell”), the haemoglobin is dense and is contracted to one pole of the cell this leaves an area where membrane surrounds a part of the cell where haemoglobin is absent. Note in this case many cells present also have the appearance of irregularly contacted cells. Clinical condition: deficiency of G6PD with oxidative damage''
	</span>		</span>
	<span style="font-size:90%"><span style="color:#808080">		<span style="font-size:90%"><span style="color:#808080">


	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:~~aaa~~.jpg\|link={{filepath:~~aaa~~.jpg}}		File:HG4.jpg\|link={{filepath:HG4.jpg}}
	</gallery>		</gallery>


	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''''Clinical Image 1: '''~~aaa~~''		'''''Clinical Image 2: '''In this instance the hemighost forms part of a wider range of irregularly shaped cells that include tear drop shapes (indicating a packed marrow) and also hypochromic and microcytic cells. This is an unusual unstable haemoglobin that also presents as a thalasaemia. Clinical condition: unstable haemoglobin ''
	</span>		</span>


	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:~~aaa~~.jpg\|link={{filepath:~~aaa~~.jpg}}		File:HG5.jpg\|link={{filepath:HG5.jpg}}
	</gallery>		</gallery>


	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	''~~'''Clinical Image 1: '''aaa''~~		'''''Clinical Image 3: '''This is s severe oxidative haemolysis in which hemighost cells can be easily seen, but note also an additional abnormal cell type is a red cells that contain no haemoglobin “ghost cells” reflecting the severity of the oxidative process. Clinical condition: severe oxidative haemolysis
	~~</span>~~
	~~<gallery widths="250px" heights="250px" >~~
	~~File:HG3.jpg\|''1.Clinical Image 1''~~
	~~File:HG4.jpg\|left\|text-center\|200px\|Clinical Image 2~~
	~~File:HG5.jpg\|left\|text-center\|200px\|Clinical Image 3~~
	~~</gallery>~~


	~~<span style="font-size:90%"><span style="color:#808080">~~
	'''Clinical Image 1''':The typical appearance of a hemighost (“blister cell”), the haemoglobin is dense and is contracted to one pole of the cell this leaves an area where membrane surrounds a part of the cell where haemoglobin is absent. Note in this case many cells present also have the appearance of irregularly contacted cells. Clinical condition: deficiency of G6PD with oxidative damage

	~~<span style="font-size:90%"><span style="color:#808080">~~
	''''Clinical Image 2:''' In this instance the hemighost forms part of a wider range of irregularly shaped cells that include tear drop shapes (indicating a packed marrow) and also hypochromic and microcytic cells. This is an unusual unstable haemoglobin that also presents as a thalasaemia. Clinical condition: unstable haemoglobin

	~~<span style="font-size:90%"><span style="color:#808080">~~
	'''Clinical Image 3:''' This is s severe oxidative haemolysis in which hemighost cells can be easily seen, but note also an additional abnormal cell type is a
	~~Red~~ cells that contain no haemoglobin “ghost cells” reflecting the severity of the oxidative process. Clinical condition: severe oxidative haemolysis

John at 08:44, 9 March 2023

2023-03-09T08:44:47Z

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 <span style="font-size:90%"><span style="color:#808080">
 <gallery widths="250px" heights="250px" >
 File:HG3.jpg|''1.Clinical Image 1''

John at 08:43, 9 March 2023

2023-03-09T08:43:22Z

← Older revision		Revision as of 10:43, 9 March 2023
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	\|A range of drugs and chemicals may cause oxidation – if the appearance is detected the clinician should take a careful clinical history		\|A range of drugs and chemicals may cause oxidation – if the appearance is detected the clinician should take a careful clinical history
	\|}		\|}
			</div>

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John at 08:42, 9 March 2023

2023-03-09T08:42:42Z

← Older revision		Revision as of 10:42, 9 March 2023
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	{\| class="wikitable" style="color:~~navy~~; background-color:#ffffff;" cellpadding="15"		<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%">
			{\| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="15"
	!colspan="1" \|'''Related to enzyme deficiency'''		!colspan="1" \|'''Related to enzyme deficiency'''
	\|-		\|-

John at 08:41, 9 March 2023

2023-03-09T08:41:53Z

← Older revision		Revision as of 10:41, 9 March 2023
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	<span style="font-size:90%~~"><span style="color:#808080"~~>		<span style="font-style:italic; font-size:90%;'' >
	'''~~Image 1:~~''' 'The typical appearance of a hemighost, the haemoglobin is dense and is contracted to one pole of the cell to leave an area where membrane surrounds an “empty” area – the blister~~.''~~		'''Images''' ''The typical appearance of a hemighost, the haemoglobin is dense and is contracted to one pole of the cell to leave an area where membrane surrounds an “empty” area – the blister.''
	~~</span>~~

	~~<span style="font-size:90%"><span style="color:#808080">~~
	'''Image 2:''' 'The cellular processes that generate hemighosts also cause damage to other cell types (indicated here by the accompanying irregularly contracted cell). If the red cell destruction is established over an extended period there may be signs of bone marrow response (e.g. polychromatic cells).''
	</span>		</span>

John at 08:40, 9 March 2023

2023-03-09T08:40:25Z

← Older revision		Revision as of 10:40, 9 March 2023
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	<~~span style~~="~~font-size:90%~~"~~><span style~~="~~color:#808080~~">		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	~~<gallery widths~~="~~180px~~" ~~heights~~="~~180px~~" >		File:File:HG1.png\|link={{filepath:File:HG1.png}}
	File:HG1.png\|1:~~Hemighost cells~~		File:HG2.jpg\|link={{filepath:HG2.jpg}}
	File:HG2.~~png~~\|~~200px\|2~~: ~~Hemighost cells (context)~~
	</gallery>		</gallery>