Keratocytes - Revision history

John at 13:53, 4 April 2023

2023-04-04T13:53:21Z

← Older revision		Revision as of 15:53, 4 April 2023
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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''''Clinical Image 1: '''In this case damage is considerable, and typical keratocytes are no longer present – being replaced by fragmented cells, however same pathological origin can still be detected with residual bites and horns. Note also the polychromatic cells formed by the marrow response to cell destruction. Clinical diagnosis: Thrombotic thrombocytopenic purpura''		'''''Clinical Image 3: '''In this case damage is considerable, and typical keratocytes are no longer present – being replaced by fragmented cells, however same pathological origin can still be detected with residual bites and horns. Note also the polychromatic cells formed by the marrow response to cell destruction. Clinical diagnosis: Thrombotic thrombocytopenic purpura''
	</span>		</span>

John at 07:32, 28 March 2023

2023-03-28T07:32:52Z

← Older revision		Revision as of 09:32, 28 March 2023
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	<span style="font-style:italic; font-size:100%;'' >		<span style="font-style:italic; font-size:100%;'' >
	'''Images:''' Note the two typical horns surrounding a central depression in the drawn image - the origin as a vacuole that has ruptured (see Pathogenesis) is easy to imagine. The ~~clinical~~ image shows one typical keratocyte (~~upper cell~~), but also emphasises the more widespread damage that ~~may~~ accompany these forms.		'''Images:''' Note the two typical horns surrounding a central depression in the drawn image - the origin as a vacuole that has ruptured (see Pathogenesis) is easy to imagine. The cartoon image shows one typical keratocyte (arrowed), but also emphasises the more widespread damage that ofetn accompany these forms with other damaged cells and precursor red cells present.
	</span>		</span>

John at 07:31, 28 March 2023

2023-03-28T07:31:35Z

← Older revision		Revision as of 09:31, 28 March 2023
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	<gallery mode="nolines" widths="240px" heights="240px" border="1px" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	File:~~Kt1~~.png\|link={{filepath:~~Kt1~~.png}}		File:Kt1A.png\|link={{filepath:Kt1A.png}}
	File:Kt2.jpg\|link={{filepath:Kt2.jpg}}		File:Kt2.jpg\|link={{filepath:Kt2.jpg}}
	</gallery>		</gallery>

John at 08:36, 9 March 2023

2023-03-09T08:36:24Z

← Older revision		Revision as of 10:36, 9 March 2023
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	'''Pitfalls'''		'''Pitfalls'''

			The keratocyte istself is quite distinctive, however be aware of the range of causes that are not limited to microvascular damage. The appearance may also be a sign of ocidative damage or Heinz body removal. Careful attention to other features is important.


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	~~Causes~~
	~~Microvascular damage: Disseminated intravascular coagulation (DIC) Thrombotic thrombocytopenic purpura (TTP) Renal disease particularly vasculitis Disseminated malignancy~~
	~~Physical trauma Defective prosthetic heart valve with turbulent flow~~
	~~Red cell fragility e.g. iron deficiency or thalassaemia~~
	Microvascular damage Removal of denatured haemoglobin arising in a range of conditions as below: oxidant damage (see also blister cells) Alpha thalassaemia Less commonly and in small numbers: liver disease, splenectomy

John at 08:33, 9 March 2023

2023-03-09T08:33:27Z

← Older revision		Revision as of 10:33, 9 March 2023
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	!colspan="1" \|'''Microvascular damage'''		!colspan="1" \|'''Microvascular damage'''
	\|-		\|-
	\|Disseminated intravascular coagulation (DIC) Thrombotic thrombocytopenic purpura (TTP) Renal disease particularly vasculitis Disseminated malignancy		\|Disseminated intravascular coagulation (DIC), Thrombotic thrombocytopenic purpura (TTP), Renal disease particularly vasculitis, Disseminated malignancy
	\|-		\|-
	!colspan="1"\| '''Physical trauma'''		!colspan="1"\| '''Physical trauma'''
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	\|Particularly defective prosthetic heart valve or valve disease with turbulent flow		\|Particularly defective prosthetic heart valve or valve disease with turbulent flow
	\|-		\|-
	\|~~Information 2~~		!colspan="1"\| '''Red cell fragility'''
	\|-		\|-
	\|~~Information 2~~		\|e.g. iron deficiency, thalassaemia, megaloblastic anaemia, MDS (look for associated features)
	\|-		\|-
	!colspan="1"\| '''~~Red cell fragility~~'''		!colspan="1"\| '''Removal of denatured haemoglobin'''
			\|-
			\|oxidant damage (see also blister cells) Alpha thalassaemia
	\|-		\|-
	\|~~e.g. iron deficiency, thalassaemia, megaloblastic anaemia, MDS (look for associated features)~~		!colspan="1"\| '''Less commonly'''
	\|-		\|-
			\|Small numbers may occur in liver disease and splenectomy
	\|}		\|}
	</div>		</div>

John at 08:30, 9 March 2023

2023-03-09T08:30:22Z

← Older revision		Revision as of 10:30, 9 March 2023
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	<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:90%">		<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:90%">
	{\| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="15"		{\| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="15"
	!colspan="1" \|'''~~Big Title~~'''		!colspan="1" \|'''Microvascular damage'''
	\|-		\|-
	\|~~Information 1~~		\|Disseminated intravascular coagulation (DIC) Thrombotic thrombocytopenic purpura (TTP) Renal disease particularly vasculitis Disseminated malignancy
	\|-		\|-
	!colspan="1"\| '''~~Big Title 2~~'''		!colspan="1"\| '''Physical trauma'''
	\|-		\|-
	\|~~Information 2~~		\|Particularly defective prosthetic heart valve or valve disease with turbulent flow
	\|-		\|-
	\|Information 2		\|Information 2
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	\|Information 2		\|Information 2
	\|-		\|-
	!colspan="1"\| '''~~Big title 3~~'''		!colspan="1"\| '''Red cell fragility'''
	\|-		\|-
	\|~~Information 3~~		\|e.g. iron deficiency, thalassaemia, megaloblastic anaemia, MDS (look for associated features)
	\|-		\|-
	\|}		\|}

John at 08:26, 9 March 2023

2023-03-09T08:26:57Z

← Older revision		Revision as of 10:26, 9 March 2023
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	'''''Clinical Image 1: '''In this case damage is considerable, and typical keratocytes are no longer present – being replaced by fragmented cells, however same pathological origin can still be detected with residual bites and horns. Note also the polychromatic cells formed by the marrow response to cell destruction. Clinical diagnosis: Thrombotic thrombocytopenic purpura''		'''''Clinical Image 1: '''In this case damage is considerable, and typical keratocytes are no longer present – being replaced by fragmented cells, however same pathological origin can still be detected with residual bites and horns. Note also the polychromatic cells formed by the marrow response to cell destruction. Clinical diagnosis: Thrombotic thrombocytopenic purpura''
	</span>		</span>

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John at 08:26, 9 March 2023

2023-03-09T08:26:32Z

← Older revision		Revision as of 10:26, 9 March 2023
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	'''Pitfalls'''		'''Pitfalls'''

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	<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:90%">		<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:90%">
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	</div>		</div>

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	Causes		Causes

John at 08:25, 9 March 2023

2023-03-09T08:25:08Z

← Older revision		Revision as of 10:25, 9 March 2023
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	'''''Clinical Image 2: '''Further typical keratocyte forms, note a cell with three horns (*) surrounding two central depressions. Here there is more extensive evidence of additional erythrocyte damage – (echinocytes, spherocytes and early fragments) and absent platelets. Clinical diagnosis: Thrombotic thrombocytopenic purpura''		'''''Clinical Image 2: '''Further typical keratocyte forms, note a cell with three horns (*) surrounding two central depressions. Here there is more extensive evidence of additional erythrocyte damage – (echinocytes, spherocytes and early fragments) and absent platelets. Clinical diagnosis: Thrombotic thrombocytopenic purpura''
	</span>		</span>



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	~~'''Clinical Image 3:'''~~		<span style="font-style:italic; font-size:90%;'' >
	<~~div class~~="~~toccolours mw~~-~~collapsible mw-collapsed"~~ style="font-size 80%; ~~overflow:auto;"~~>		'''''Clinical Image 1: '''In this case damage is considerable, and typical keratocytes are no longer present – being replaced by fragmented cells, however same pathological origin can still be detected with residual bites and horns. Note also the polychromatic cells formed by the marrow response to cell destruction. Clinical diagnosis: Thrombotic thrombocytopenic purpura''
	In this case damage is considerable, and typical keratocytes are no longer present – being replaced by fragmented cells, however same pathological origin can still be detected with residual bites and horns. Note also the polychromatic cells formed by the marrow response to cell destruction. Clinical diagnosis: Thrombotic thrombocytopenic purpura		</span>
	</~~div~~>

John at 08:23, 9 March 2023

2023-03-09T08:23:06Z

← Older revision		Revision as of 10:23, 9 March 2023
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	</span>		</span>



	~~'''Clinical Image 1''':~~
	~~<div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;">~~
	~~Typical keratocyte forms, most have two horns surrounding a central depression. There are also some echinocytes present. Clinical diagnosis: Oxidative damage and Heinz body removal~~
	~~</div>~~

	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
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	~~''''Clinical Image 2:'''~~		<span style="font-style:italic; font-size:90%;'' >
	<~~div class~~="~~toccolours mw~~-~~collapsible mw-collapsed"~~ style="font-size 80%; ~~overflow:auto;"~~>		'''''Clinical Image 2: '''Further typical keratocyte forms, note a cell with three horns (*) surrounding two central depressions. Here there is more extensive evidence of additional erythrocyte damage – (echinocytes, spherocytes and early fragments) and absent platelets. Clinical diagnosis: Thrombotic thrombocytopenic purpura''
	Further typical keratocyte forms, note a cell with three horns (*) surrounding two central depressions. Here there is more extensive evidence of additional erythrocyte damage – (echinocytes, spherocytes and early fragments) and absent platelets. Clinical diagnosis: Thrombotic thrombocytopenic purpura		</span>
	</~~div~~>