Marker patterns erythroid or megakaryocyte differentiation - Revision history

John at 10:43, 2 February 2024

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John at 10:52, 31 January 2024

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John: Created page with "----
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2024-01-31T10:51:17Z

Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <span style="font-size:90%>'''Acute erythroid leukaemia (AEL)'''</br>This may be a difficult diagnosis since markers will often not allow cells to be distinguished from a re..."

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<span style="font-size:90%>'''Acute erythroid leukaemia (AEL)'''</br>This may be a difficult diagnosis since markers will often not allow cells to be distinguished from a reactive erythroid expansion, and the overlap with cases of myelodysplasia-related AML may have a marked erythroid expansion. In such cases the diagnosis of AEL requires careful exclusion of other disorders by correlation with morphology and other tests.

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!colspan="2" <span style="font-size:90%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with erythroid differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white"></span>
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''General:''' In AEL cases may vary but may have very weak expression of [[CD45]] and [[HLA-DR}}. In contrast [[CD34]] and often [[CD117]] will be detected.
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|colspan="2" style = "font-size:90%; color:black;" |'''Specific:''' Markers of erythroid differentiation are helpful, but require careful interpretation to discriminate from other causes (described below).
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD36]]'''
|colspan="1" style = "font-size:84%;"|Expression is expected, but is not fully lineage specific as it may be seen in other AML forms including cases with monocytic or megakaryocytic differentiation.
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD71]]'''
|colspan="1" style = "font-size:84%;"|A good marker of early erythroid differentiation that is expected to be expressed, although again not fully lineage specific and also found on reactive erythroid precursors.
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD235]]'''
|colspan="1" style = "font-size:84%;"|A good marker of erythroid differentiation; however like CD72 does not distinguish neoplastic and reactive cells. It is acquired later in erythroid differentiation and therefore may not be expressed or be confined to a sub-population in AEL.
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|colspan="2" style = "font-size:90%; color:black;" |'''Abberant phenotype:''' Expression of CD13, CD38 or CD4 may be encountered in some cases.
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with megakaryocytic differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white">
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Most often [[CD34]], [[CD45]] and [[HLA-DR]] are weak or negative, although [[CD13]] and [[CD33]] may be expressed
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD41]]'''
|colspan="1" style = "font-size:84%;"|Platelet glycoprotein IIbIIIa
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD61]]'''
|colspan="1" style = "font-size:84%;"|Platelet glycoprotein IIIa
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD36]]'''
|colspan="1" style = "font-size:84%;"|Relatively non-specific (seen in erythroid and monocytic leukaemias) but often strongly expressed
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with basophilic differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white">
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |comment
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD22]]'''
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD123]]'''
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD203]]'''
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD11b]]'''
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