Myeloid lineage-associated markers - Revision history

John at 17:57, 5 January 2024

2024-01-05T17:57:33Z

← Older revision		Revision as of 19:57, 5 January 2024
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	----		----
	These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider a diagnosis of MPAL.</br></br>		''These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider a diagnosis of MPAL''</br></br>
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John at 17:57, 5 January 2024

2024-01-05T17:57:05Z

← Older revision		Revision as of 19:57, 5 January 2024
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	----		----
	These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider diagnosis of MPAL.</br></br>		These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider a diagnosis of MPAL.</br></br>
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John at 17:56, 5 January 2024

2024-01-05T17:56:17Z

← Older revision		Revision as of 19:56, 5 January 2024
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	----		----
	These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider diagnosis of MPAL.</br>		These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider diagnosis of MPAL.</br></br>
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John at 17:55, 5 January 2024

2024-01-05T17:55:57Z

← Older revision		Revision as of 19:55, 5 January 2024
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	----		----
			These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider diagnosis of MPAL.</br>
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John at 17:51, 5 January 2024

2024-01-05T17:51:52Z

← Older revision		Revision as of 19:51, 5 January 2024
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	\|colspan="2" style = "font-size:90%; color:black; background:lightgrey" \|'''Assignment of myeloid lineage: Lineage-associated markers'''		\|colspan="2" style = "font-size:90%; color:black; background:lightgrey" \|'''Assignment of myeloid lineage: Lineage-associated markers'''
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1"\|~~'''Pattern 2''':</br>~~Myeloid lineage assignment using these markers requires that at least ~~'''~~two myeloid lineage-associated~~'''~~ markers are present		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1"\|Myeloid lineage assignment using these markers requires that at least two myeloid lineage-associated markers are present
	\|-		\|-
	\|colspan="1" style = "font-size:90%; color:black;" \|'''[[CD117]]'''		\|colspan="1" style = "font-size:90%; color:black;" \|'''[[CD117]]'''

John at 17:50, 5 January 2024

2024-01-05T17:50:58Z

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	\|colspan="2" style = "font-size:90%; color:black; background:lightgrey" \|Assignment of myeloid lineage: Lineage-associated markers		\|colspan="2" style = "font-size:90%; color:black; background:lightgrey" \|'''Assignment of myeloid lineage: Lineage-associated markers'''
	\|-		\|-
	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1"\|'''Pattern 2''':</br>At least '''two myeloid lineage-associated''' markers are ~~present '''and''' there are no lineage defining markers of T or B cells '''and''' no more than one T-cell '''or''' B-cell lineage-associated marker is~~ present		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1"\|'''Pattern 2''':</br>Myeloid lineage assignment using these markers requires that at least '''two myeloid lineage-associated''' markers are present
	\|-		\|-
	\|colspan="1" style = "font-size:90%; color:black;" \|'''[[CD117]]'''		\|colspan="1" style = "font-size:90%; color:black;" \|'''[[CD117]]'''

John at 17:49, 5 January 2024

2024-01-05T17:49:40Z

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	\|colspan="2" style = "font-size:90%; color:black; background:lightgrey" \|~~'''Pattern 2''':</br>At least '''two~~ myeloid lineage-associated~~''' markers are present '''and''' there are no lineage defining~~ markers ~~of T or B cells '''and''' no more than one T-cell '''or''' B-cell lineage-associated marker is present~~		\|colspan="2" style = "font-size:90%; color:black; background:lightgrey" \|Assignment of myeloid lineage: Lineage-associated markers
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	\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1"\|		\|colspan="2" style = "font-size:90%; color:black; background:#ddeee1"\|'''Pattern 2''':</br>At least '''two myeloid lineage-associated''' markers are present '''and''' there are no lineage defining markers of T or B cells '''and''' no more than one T-cell '''or''' B-cell lineage-associated marker is present
	\|-		\|-
	\|colspan="1" style = "font-size:90%; color:black;" \|'''[[CD117]]'''		\|colspan="1" style = "font-size:90%; color:black;" \|'''[[CD117]]'''

John at 17:48, 5 January 2024

2024-01-05T17:48:25Z

← Older revision		Revision as of 19:48, 5 January 2024
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	~~'''Table: Marker patterns that allow definite assignment of acute myeloid lineage'''~~


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John at 10:58, 5 January 2024

2024-01-05T10:58:04Z

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	\| colspan="1"''\|[[~~The flow cytometric diagnosis~~ of AML\|Return to previous page]]''		\| colspan="1"''\|[[Tables of diagnostic markers supporting lineage assignment in AML\|Return to previous page]]''
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John: Created page with "----
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---- '''Table: Marker patterns that allow definite assignment of acute myeloid lineage'''
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2023-12-21T12:46:23Z

Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- '''Table: Marker patterns that allow definite assignment of acute myeloid lineage''' <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width:..."

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| colspan="1"''|[[The flow cytometric diagnosis of AML|Return to previous page]]''
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'''Table: Marker patterns that allow definite assignment of acute myeloid lineage'''

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{| class="wikitable" style="border-style: solid; border-width: 5px; color:black"
|colspan="2" style = "font-size:90%; color:black; background:lightgrey" |'''Pattern 2''':</br>At least '''two myeloid lineage-associated''' markers are present '''and''' there are no lineage defining markers of T or B cells '''and''' no more than one T-cell '''or''' B-cell lineage-associated marker is present
|-
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1"|
|-
|colspan="1" style = "font-size:90%; color:black;" |'''[[CD117]]'''
|colspan="1" style = "font-size:84%;"|An early marker of myeloid lineage, seen in up to 80% of AML and vauable in recognising more primitive differentaiion forms (note that aberrant expression is seen in up to 20% of ALL cases)
|-
|colspan="1" style = "font-size:90%; color:black;" |'''[[CD33]]'''
|colspan="1" style = "font-size:84%;"|A good marker for AML, particularly for those cases with granulocytic maturation, CD33 is often less strongly expressed in AML with monocytic dfferentiation and strongly expressed in APL.
|-
|colspan="1" style = "font-size:90%; color:black;" |'''[[CD13]]'''
|colspan="1" style = "font-size:84%;"|A good lineage marker for AML that is acquired a little later in differentation than CD117 or CD33; expression of CD13 is often higher than CD33 in AML with monocytic differentiation.
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