SC poikilocytes - Revision history

John at 12:09, 23 March 2023

2023-03-23T12:09:02Z

← Older revision		Revision as of 14:09, 23 March 2023
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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:SCP3.jpg\|		File:SCP3.jpg\|link={{filepath:SCP3.jpg}}
	</gallery>		</gallery>


	~~'''''Clinical Image 1:'''~~		<span style="font-style:italic; font-size:90%;'' >
	<~~div class~~="~~toccolours mw-collapsible mw~~-~~collapsed"~~ style="font-size 80%; ~~overflow:auto;"~~>		'''Clinical Image 1''': SC poikilocyte in the appropriate cellular context - the appearance closely resembles the cell in the main image 1 (above)''
	''SC poikilocyte in the appropriate cellular context - the appearance closely resembles the cell in the main image 1 (above)''
	</div>		</div>


	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
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	'''''Clinical Image 2:'''		<span style="font-style:italic; font-size:90%;'' >
	~~<div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow~~:~~auto;">~~		'''Clinical Image 2''': A second image from the same case showing a similar branched poikilocyte but with a more rounded cell body''
	A second image from the same case showing a similar branched poikilocyte but with a more rounded cell body''
	</div>		</div>

John at 12:06, 23 March 2023

2023-03-23T12:06:33Z

← Older revision		Revision as of 14:06, 23 March 2023
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	~~__NOTOC__~~

	'''Derivation:''' ''SC = arising in HbSC disease; poikilocyte = irregularly shaped cell''		'''Derivation:''' ''SC = arising in HbSC disease; poikilocyte = irregularly shaped cell''

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	<gallery widths="~~180px~~" heights="~~180px~~" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	File:SCP1.png\|link={{filepath:SCP1.png}}		File:SCP1.png\|link={{filepath:SCP1.png}}
			File:SCP2.jpg\|link={{filepath:SCP2.jpg}}
	</gallery>		</gallery>


			<span style="font-style:italic; font-size:90%;'' >
	~~'''Image 1 SC poikilocyte'''~~		Showing the typical elongated form with two straight branches, variations on the theme are characteristic (although often rare) in SC disease. Note that they will be accompanied by other diagnostic features such as the typical contracted cells and target cells of HbSC disease.
	<~~div class~~="~~toccolours mw~~-~~collapsible mw-collapsed"~~ style="font-size 80%; ~~overflow:auto;"~~>
	Showing the typical elongated form with two straight branches, variations on the theme are characteristic (although often rare) in SC disease.
	~~</div>~~

	~~<gallery widths="180px" heights="180px" >~~
	~~File:SCP2.png\|link={{filepath:SCP2.png}}~~
	~~</gallery>~~


	~~'''''Image 2: SC poikilocyes in context'''~~
	~~<div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;">~~
	~~In this case~~ accompanied by the typical contracted cells and target cells of HbSC disease.
	</div>		</div>

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	<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%">		<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%">
	{\| class="wikitable" style="color:~~navy~~; background-color:#ffffff;" cellpadding="15"		{\| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="15"
	!colspan="1"\|Cause		!colspan="1"\|Cause
	\|-		\|-

John: Created page with "NOTOC '''Derivation:''' ''SC = arising in HbSC disease; poikilocyte = irregularly shaped cell'' ---- '''Appearance''' A dense and often elongated cell that may resemble a poorly formed sickle cell or an unusually shaped poikilocyte, but is characterised particularly by irregular short branches that project from the cell body. File:SCP1.png|link={{filepath:SCP1.png}} '''Image 1 SC poikilocyte'''

2023-02-19T17:55:51Z

Created page with "NOTOC '''Derivation:''' ''SC = arising in HbSC disease; poikilocyte = irregularly shaped cell'' ---- '''Appearance''' A dense and often elongated cell that may resemble a poorly formed sickle cell or an unusually shaped poikilocyte, but is characterised particularly by irregular short branches that project from the cell body. <gallery widths="180px" heights="180px" > File:SCP1.png|link={{filepath:SCP1.png}} </gallery> '''Image 1 SC poikilocyte''' <div clas..."

New page
NOTOC

'''Derivation:''' ''SC = arising in HbSC disease; poikilocyte = irregularly shaped cell''

----

'''Appearance'''

A dense and often elongated cell that may resemble a poorly formed sickle cell or an unusually shaped poikilocyte, but is characterised particularly by irregular short branches that project from the cell body.

<gallery widths="180px" heights="180px" >
File:SCP1.png|link={{filepath:SCP1.png}}
</gallery>

'''Image 1 SC poikilocyte'''
<div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;">
Showing the typical elongated form with two straight branches, variations on the theme are characteristic (although often rare) in SC disease.
</div>

<gallery widths="180px" heights="180px" >
File:SCP2.png|link={{filepath:SCP2.png}}
</gallery>

'''''Image 2: SC poikilocyes in context'''
<div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;">
In this case accompanied by the typical contracted cells and target cells of HbSC disease.
</div>

----

'''Significance'''

These cells are formed when sickle haemoglobin (HbS) is present together with haemoglobin C (HbC) to form a compound heterozygote disorder (HbSC disease)

'''Pitfalls'''

Providing the dense elongated shape is recognised with the typical branches, then the cell is distinctive. However, these forms may be uncommon or absent from otherwise typical HbSC. Look also for boat-shaped cells, contracted cells and target cells.

----

'''Causes'''

<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%">
{| class="wikitable" style="color:navy; background-color:#ffffff;" cellpadding="15"
!colspan="1"|Cause
|-
|These cells are typical of HbSC disease, but should occur in the appropriate context of target cells and irregularly contracted cells.
|}
</div>

----

'''Clinical Examples'''

<gallery widths="250px" heights="250px" >
File:SCP3.jpg|
</gallery>

'''''Clinical Image 1:'''
<div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;">
''SC poikilocyte in the appropriate cellular context - the appearance closely resembles the cell in the main image 1 (above)''
</div>

<gallery widths="250px" heights="250px" >
File:SCP4.jpg|
</gallery>

'''''Clinical Image 2:'''
<div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;">
A second image from the same case showing a similar branched poikilocyte but with a more rounded cell body''
</div>

----

'''Pathobiology'''

Both HbS and HbC have altered solubility in their deoxygenated states. In this case the typical elongated cell presumably arises from the formation of long HbS polymers while the reduced solubility and tendency to crystallisation of HbC gives rise to irregular branches.

----