Flow cytometry:AUL

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Acute Undifferentiated Leukaemia (AUL)

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What features must be met to diagnose acute undifferentiated leukaemia
Requirement 1
No lineage can be assigned by lineage-defining markers of myeloid, B-lymphoid or T-lymphoid lineage Review Criteria: Myeloid B-Lymphoid T-Lymphoid
Requirement 2
Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider whether marker patterns suggest any of the following: acute megakaryocytic leukaemia Non haematopoietic tumours Blastic plasma dendritic cell neoplasm Plasma cell leukaemia
Requirement 3
Consider whether the case may be better described as Acute Leukaemia of Ambiguous Lineage - not otherwise specified (ALAL-NOS) - see guidance ALAL-NOS

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